Translational Technologies and Resources

** This Unit is Currently Not Active (Pending Extramural Funding) **

Mission

Modern biomedical research requires a cadre of institutional Core Facilities (e.g., Flow Cytometry and Biobanking) to efficiently support clinical and translational science at the state-of-the-art. The overall goal of the Translational Technologies and Resources Unit (TTR) is to maximize the efficient use of UVM’s Core Facilities by CCTS investigators, and ensure our faculty is aware of, and has access to, Core Facilities at regional institutions as needed. Key responsibilities include:

  • Improving knowledge of, access to, and integration of existing and new UVM Core Facilities through the development of a TTR website, electronic and hard copy brochures, and sponsorship of workshops for investigators and organizational meetings for Core Facility Directors.
  • Promoting the development and use of novel technologies and approaches through discussion and consultation services with new investigators, Fellows, and graduate students, and the development of a common application format (“single point of entry”) for Core Facility services.
  • Providing leadership in the area of biomarker discovery, development, implementation, and evaluation through the Translational Biomarker Core Facility
  • Continuing local and regional leadership by coordinating core facilities, including the development of easily accessed databases of facilities and specimens

Resources & Services

  • Imaging From Molecules to Organisms: comprises Core Facilities that deal with methods for imaging biologically important targets. Core Facilities include: the Center for X-Ray Crystallography; the Cryo-Electron Microscopy Facility; the widely used Microscope Imaging Facility; the Experimental Pathology Division specializing in immunohistology and in situ hybridization; and the Functional and Structural MRI Core Facility.
  • Molecular Genotyping and Phenotyping: includes Core Facilities that deal with characterizing individuals through quantitative measurement of biochemicals such as proteins, genes, and intermediate metabolites. Member Cores include: the Metabolic Mass Spectrometry Core Facility; the Harry Hood Bassett Flow Cytometry Facility; three linked genetic Core Facilities focused on DNA Analysis and Sequencing, Microarray Expression analyses, and Molecular Bioinformatics; the Vermont Genetics Network Proteomics Core Facility including both mass spectroscopy and Proteomic and Genomic Bioinformatics; the Peptide Synthesis and Analysis Core Facility; and the Translational Biomarker Core Facility.
  • Physiological Phenotyping: includes Core Facilities that address research at the physiological level or the level of the whole organism. Member Cores include the Human Physiology Core Facility, the Bionutrition Core Facility, three linked Cores dealing with animal resources (the UVM Animal Resources Center, the Transgenic Mouse Facility, and the Environmental Pathology Inhalation Facility), the UVM/State Health Laboratory BSL-3 Facility, and the Stem Cell Core Facility.